PERAMPANEL AND CHILDHOOD ABSENCE EPILEPSY: A REAL LIFE EXPERIENCE

Perampanel and childhood absence epilepsy: A real life experience

ObjectivesThe aim of our study was to evaluate the effectiveness and tolerability of perampanel (PER) as first add-on and as second line monotherapy in subjects with childhood absence epilepsy.MethodsOur sample consisted of 20 patients with childhood absence epilepsy, aged between 8 and 10, already in therapy with a first antiseizure medication wit

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Prospective study of human herpesvirus 8 oral shedding, viremia, and serological status among human immunodeficiency virus seropositive and seronegative individuals in Sao Paulo, Brazil

Human herpesvirus 8 (HHV-8) is a gamma-herpesvirus and etiological agent of all forms of Kaposi sarcoma (KS).Saliva may play an important role in HHV-8 transmission in specific populations.Little is known about HHV-8 oral shedding pattern and the possible correlation with the HHV-8 serological profile and viremia.A prospective study was conducted o

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Therapeutic targeting of alternative splicing

Gene transcription leads to the generation of pre-mRNA molecules which contain both coding sequences (exons) and intervening non-coding sequences (introns).The primary transcript needs further processing which involves the excision of introns and ligation of exons.This process is called RNA splicing.Nearly all primary transcripts undergo alternativ

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